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1

Greenlandic Inuit show genetic signatures of diet and climate adaptation

Fumagalli, M., Moltke, I., Grarup, N., Racimo, F., Bjerregaard, P., Jorgensen, M. E., Korneliussen, T. S., Gerbault, P., Skotte, L., Linneberg, A., Christensen, C., Brandslund, I., Jorgensen, T., Huer

Journal:

Year:

2015

Language:

english

File:

PDF, 596 KB

english, 2015

2

Outpatient Nursing Clinic for Congenital Heart Disease Patients

Berg, Selina Kikkenborg, Hertz, Pernille Grarup

Journal:

The Journal of Cardiovascular Nursing

Year:

2007

Language:

english

File:

PDF, 405 KB

english, 2007

3

vApp

Schmidt, René W., Grarup, Steffen

Journal:

ACM SIGOPS Operating Systems Review

Year:

2010

Language:

english

File:

PDF, 434 KB

english, 2010

4

The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit

Pedersen, C.-E. T., Lohmueller, K. E., Grarup, N., Bjerregaard, P., Hansen, T., Siegismund, H. R., Moltke, I., Albrechtsen, A.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.63 MB

english, 2016

5

Associations between birth weight and glucose intolerance in adulthood among Greenlandic Inuit

Falberg Rønn, Pernille, Eika Jørgensen, Marit, Steenberg Smith, Lærke, Bjerregaard, Peter, Katrine Dahl-Petersen, Inger, Viskum Lytken Larsen, Christina, Grarup, Niels, Stig Andersen, Gregers

Journal:

Diabetes Research and Clinical Practice

Year:

2019

File:

PDF, 760 KB

2019

6

Hacking the hospital environment: young adults designing youth-friendly hospital rooms together with young people with cancer experiences

Boisen, Kirsten A., Boisen, Anne, Thomsen, Stine Legarth, Matthiesen, Simon Meggers, Hjerming, Maiken, Hertz, Pernille Grarup

Journal:

International Journal of Adolescent Medicine and Health

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

7

Increased frequency of rare missense PPP1R3B variants among Danish patients with type 2 diabetes

Niazi, Robina Khan, Sun, Jihua, Have, Christian Theil, Hollensted, Mette, Linneberg, Allan, Pedersen, Oluf, Nielsen, Jens Steen, Rungby, Jørgen, Grarup, Niels, Hansen, Torben, Gjesing, Anette Prior, H

Journal:

Year:

2019

Language:

english

File:

PDF, 684 KB

english, 2019

8

Associations between birth weight and glucose intolerance in adulthood among Greenlandic Inuit

Falberg Rønn, Pernille, Eika Jørgensen, Marit, Steenberg Smith, Lærke, Bjerregaard, Peter, Katrine Dahl-Petersen, Inger, Viskum Lytken Larsen, Christina, Grarup, Niels, Stig Andersen, Gregers

Journal:

Diabetes Research and Clinical Practice

Year:

2019

Language:

english

File:

PDF, 760 KB

english, 2019

9

Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans: a cross-sectional study

RÃ¸nn, Pernille Falberg, Andersen, Gregers Stig, Lauritzen, Torsten, Christensen, Dirk Lund, Aadahl, Mette, Carstensen, Bendix, Grarup, Niels, JÃ¸rgensen, Marit Eika

Journal:

Year:

2020

File:

PDF, 625 KB

2020

10

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

Flannick, Jason, Thorleifsson, Gudmar, Beer, Nicola L, Jacobs, Suzanne B R, Grarup, Niels, Burtt, Noël P, Mahajan, Anubha, Fuchsberger, Christian, Atzmon, Gil, Benediktsson, Rafn, Blangero, John, Bowd

Journal:

Nature Genetics

Year:

2014

Language:

english

File:

PDF, 605 KB

english, 2014

11

Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels

Mahendran, Yuvaraj, Jonsson, Anna, Have, Christian T., Allin, Kristine H., Witte, Daniel R., Jørgensen, Marit E., Grarup, Niels, Pedersen, Oluf, Kilpeläinen, Tuomas O., Hansen, Torben

Journal:

Year:

2017

Language:

english

File:

PDF, 333 KB

english, 2017

12

Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population

Appel, Emil V. R., Moltke, Ida, Jørgensen, Marit E., Bjerregaard, Peter, Linneberg, Allan, Pedersen, Oluf, Albrechtsen, Anders, Hansen, Torben, Grarup, Niels

Journal:

European Journal of Human Genetics

Year:

2018

Language:

english

File:

PDF, 709 KB

english, 2018

13

Type 2 diabetes risk allele nearCENTD2is associated with decreased glucose-stimulated insulin release

T. Nielsen, T. Sparsø, N. Grarup, T. Jørgensen, C. Pisinger, D. R. Witte, T. Hansen, O. Pedersen, Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium

Journal:

Year:

2011

Language:

english

File:

PDF, 117 KB

english, 2011

14

Studies of the variability of the hepatocyte nuclear factor-1β (HNF-1β / TCF2) and the dimerization cofactor of HNF-1 (DcoH / PCBD) genes in relation to type 2 diabetes mellitus and β-cell function

Jakob Ek, Niels Grarup, Søren A. Urhammer, Peter H. Gæde, Thomas Drivsholm, Knut Borch-Johnsen, Torben Hansen, Oluf Pedersen

Journal:

Year:

2001

Language:

english

File:

PDF, 41 KB

english, 2001

15

Estimation of allele frequency and association mapping using next-generation sequencing data

Su Yeon Kim, Kirk E Lohmueller, Anders Albrechtsen, Yingrui Li, Thorfinn Korneliussen, Geng Tian, Niels Grarup, Tao Jiang, Gitte Andersen, Daniel Witte, Torben Jorgensen, Torben Hansen, Oluf Pedersen,

Journal:

BMC Bioinformatics

Year:

2011

Language:

english

File:

PDF, 523 KB

english, 2011

16

A glycogene mutation map for discovery of diseases of glycosylation

Hansen, L., Lind-Thomsen, A., Joshi, H. J., Pedersen, N. B., Have, C. T., Kong, Y., Wang, S., Sparso, T., Grarup, N., Vester-Christensen, M. B., Schjoldager, K., Freeze, H. H., Hansen, T., Pedersen, O

Journal:

Year:

2015

Language:

english

File:

PDF, 720 KB

english, 2015

17

Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population

Grarup, Niels, Moltke, Ida, Andersen, Mette K., Bjerregaard, Peter, Larsen, Christina V. L., Dahl-Petersen, Inger K., Jørsboe, Emil, Tiwari, Hemant K., Hopkins, Scarlett E., Wiener, Howard W., Boyer,

Journal:

Year:

2018

Language:

english

File:

PDF, 834 KB

english, 2018

18

P3630Genetic risk score of insulin resistance risk variants is associated with increased risk of coronary artery disease in patients referred to coronary angiography

Kuhr Skals, R, Lukacs Krogager, M, Rosenbaum Appel, E V, Schnurr, T M, Theil Have, C, Gislason, G, Enghusen, H, Koeber, L, Engstroem, T, Stender, S, Hansen, T, Grarup, N, Andersson, C, Torp-Pedersen,

Journal:

European Heart Journal

Year:

2018

Language:

english

File:

PDF, 401 KB

english, 2018

19

Identification of novel LEPR mutations in Pakistani families with morbid childhood obesity

Niazi, Robina Khan, Gjesing, Anette P, Hollensted, Mette, Have, Christian Theil, Grarup, Niels, Pedersen, Oluf, Ullah, Asmat, Shahid, Gulbin, Ahmad, Wasim, Gul, Asma, Hansen, Torben

Journal:

BMC Medical Genetics

Year:

2018

Language:

english

File:

PDF, 823 KB

english, 2018

20

PCR and DNA sequencing in establishing the aetiology of bacterial infections in children

ANN SOFIE GLEESEN, CECILIE GRARUP, RIMTAS DARGIS, KELD ANDRESEN, JENS JØRGEN CHRISTENSEN, MICHAEL KEMP

Journal:

Year:

2008

Language:

english

File:

PDF, 53 KB

english, 2008

21

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

Moltke, Ida, Grarup, Niels, Jørgensen, Marit E., Bjerregaard, Peter, Treebak, Jonas T., Fumagalli, Matteo, Korneliussen, Thorfinn S., Andersen, Marianne A., Nielsen, Thomas S., Krarup, Nikolaj T., Gje

Journal:

Year:

2014

Language:

english

File:

PDF, 2.79 MB

english, 2014

22

Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations

Salanti, G., Southam, L., Altshuler, D., Ardlie, K., Barroso, I., Boehnke, M., Cornelis, M. C., Frayling, T. M., Grallert, H., Grarup, N., Groop, L., Hansen, T., Hattersley, A. T., Hu, F. B., Hveem, K

Journal:

American Journal of Epidemiology

Year:

2009

Language:

english

File:

PDF, 204 KB

english, 2009

23

Challenges, successes and patterns of enrolment in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial

Grarup, J, Rappoport, C, Engen, NW, Carey, C, Hudson, F, Denning, E, Sharma, S, Florence, E, Vjecha, MJ

Journal:

Year:

2015

Language:

english

File:

PDF, 443 KB

english, 2015

24

Genome-wide association study of T-wave morphology

Kanters, J.K., Grarup, N., Graff, C., Nielsen, J., Linneberg, A., Hansen, T., Olesen, M.S.

Journal:

Journal of Electrocardiology

Year:

2018

Language:

english

File:

PDF, 64 KB

english, 2018

25

What Is the Contribution of Two Genetic Variants Regulating VEGF Levels to Type 2 Diabetes Risk and to Microvascular Complications?

Bonnefond, Amélie, Saulnier, Pierre-Jean, Stathopoulou, Maria G., Grarup, Niels, Ndiaye, Ndeye Coumba, Roussel, Ronan, Nezhad, Mohsen Azimi, Dechaume, Aurélie, Lantieri, Olivier, Hercberg, Serge, Laur

Journal:

Year:

2013

Language:

english

File:

PDF, 175 KB

english, 2013

26

Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight

Moen, Gunn-Helen, Beaumont, Robin N, Grarup, Niels, Sommer, Christine, Shields, Beverley M, Lawlor, Deborah A, Freathy, Rachel M, Evans, David M, Warrington, Nicole M

Journal:

International Journal of Epidemiology

Year:

2020

File:

PDF, 513 KB

2020

27

G-allele of Intronic rs10830963 in MTNR1B Confers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release: Studies Involving 19,605 Europeans

Sparso, T., Bonnefond, A., Andersson, E., Bouatia-Naji, N., Holmkvist, J., Wegner, L., Grarup, N., Gjesing, A. P., Banasik, K., Cavalcanti-Proenca, C., Marchand, M., Vaxillaire, M., Charpentier, G., J

Journal:

Year:

2009

Language:

english

File:

PDF, 158 KB

english, 2009

28

Genome-wide association studies of human adiposity: Zooming in on synapses

C. H. Sandholt, N. Grarup, O. Pedersen, T. Hansen

Year:

2015

Language:

english

File:

PDF, 975 KB

english, 2015

29

The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes

Nielsen, Trine, Burgdorf, Kristoffer Sølvsten, Grarup, Niels, Borch-Johnsen, Knut, Hansen, Torben, Jørgensen, Torben, Pedersen, Oluf, Andersen, Gitte

Journal:

Journal of Hypertension

Year:

2008

Language:

english

File:

PDF, 104 KB

english, 2008

30

Diabetic microvascular complications are not associated with two polymorphisms in the GLUT‐1 and PC‐1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients

Tarnow, Lise, Grarup, Niels, Hansen, Torben, Parving, Hans‐Henrik, Pedersen, Oluf

Journal:

Nephrology Dialysis Transplantation

Year:

2001

Language:

english

File:

PDF, 65 KB

english, 2001

31

Targeted Knockout of the Vegfa Gene in the Retina by Subretinal Injection of RNP Complexes Containing Cas9 Protein and Modified sgRNAs

Holmgaard, Andreas Braae, Askou, Anne Louise, Jensen, Emilie Grarup, Alsing, Sidsel, Bak, Rasmus O., Mikkelsen, Jacob Giehm, Corydon, Thomas J.

Journal:

Molecular Therapy

Year:

2020

File:

PDF, 4.80 MB

2020

32

A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe

Mocroft, A., Reiss, P., Rakhmanova, A., Banhegyi, D., Phillips, A. N., De Wit, S., Ristola, M., Lundgren, J. D., Grarup, J., Kirk, O.

Journal:

Year:

2014

Language:

english

File:

PDF, 311 KB

english, 2014

33

Variation and association to diabetes in 2000 full mtDNA sequences mined from an exome study in a Danish population

Li, Shengting, Besenbacher, Soren, Li, Yingrui, Kristiansen, Karsten, Grarup, Niels, Albrechtsen, Anders, Sparsø, Thomas, Korneliussen, Thorfinn, Hansen, Torben, Wang, Jun, Nielsen, Rasmus, Pedersen,

Journal:

European Journal of Human Genetics

Year:

2014

Language:

english

File:

PDF, 782 KB

english, 2014

34

A genetic risk score of 45 coronary artery disease risk variants associates with increased risk of myocardial infarction in 6041 Danish individuals

Krarup, N.T., Borglykke, A., Allin, K.H., Sandholt, C.H., Justesen, J.M., Andersson, E.A., Grarup, N., Jørgensen, T., Pedersen, O., Hansen, T.

Journal:

Atherosclerosis

Year:

2015

Language:

english

File:

PDF, 249 KB

english, 2015

35

Natural Selection Affects Multiple Aspects of Genetic Variation at Putatively Neutral Sites across the Human Genome

Lohmueller, Kirk E., Albrechtsen, Anders, Li, Yingrui, Kim, Su Yeon, Korneliussen, Thorfinn, Vinckenbosch, Nicolas, Tian, Geng, Huerta-Sanchez, Emilia, Feder, Alison F., Grarup, Niels, Jørgensen, Torb

Journal:

Year:

2011

Language:

english

File:

PDF, 516 KB

english, 2011

36

Genetics of Type 2 Diabetes: the Power of Isolated Populations

Andersen, Mette Korre, Pedersen, Casper-Emil Tingskov, Moltke, Ida, Hansen, Torben, Albrechtsen, Anders, Grarup, Niels

Journal:

Current Diabetes Reports

Year:

2016

Language:

english

File:

PDF, 1.42 MB

english, 2016

37

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

Surendran, Praveen, Drenos, Fotios, Young, Robin, Warren, Helen, Cook, James P, Manning, Alisa K, Grarup, Niels, Sim, Xueling, Barnes, Daniel R, Witkowska, Kate, Staley, James R, Tragante, Vinicius, T

Journal:

Nature Genetics

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

38

Numerous Brugada syndrome–associated genetic variants have no effect on J-point elevation, syncope susceptibility, malignant cardiac arrhythmia, and all-cause mortality

Ghouse, Jonas, Have, Christian T., Skov, Morten W., Andreasen, Laura, Ahlberg, Gustav, Nielsen, Jonas B., Skaaby, Tea, Olesen, Søren-Peter, Grarup, Niels, Linneberg, Allan, Pedersen, Oluf, Vestergaard

Journal:

Genetics in Medicine

Year:

2016

Language:

english

File:

PDF, 816 KB

english, 2016

39

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Scott, R. A., Freitag, D. F., Li, L., Chu, A. Y., Surendran, P., Young, R., Grarup, N., Stancakova, A., Chen, Y., Varga, T. V., Yaghootkar, H., Luan, J., Zhao, J. H., Willems, S. M., Wessel, J., Wang,

Journal:

Science Translational Medicine

Year:

2016

Language:

english

File:

PDF, 1.09 MB

english, 2016

40

Genetical component of the QT interval is associated with increased mortality in the general population

Kanters, J.K., Ghouse, J., Skov, M.W., Isaksen, J.L., Christiansen, M., Graff, C., Grarup, N., Have, C. Theil, Linneberg, A., Hansen, T., Olesen, M.S.

Journal:

Journal of Electrocardiology

Year:

2019

File:

PDF, 47 KB

2019

41

Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus

T. Hansen, L. Ambye, N. Grarup, L. Hansen, S. M. Echwald, J. Ferrer, O. Pedersen

Journal:

Year:

2001

Language:

english

File:

PDF, 70 KB

english, 2001

42

Common Variation in LMNA Increases Susceptibility to Type 2 Diabetes and Associates With Elevated Fasting Glycemia and Estimates of Body Fat and Height in the General Population: Studies of 7,495 Danish Whites

Wegner, L., Andersen, G., Sparso, T., Grarup, N., Glumer, C., Borch-Johnsen, K., Jorgensen, T., Hansen, T., Pedersen, O.

Journal:

Year:

2007

Language:

english

File:

PDF, 158 KB

english, 2007

43

Carriers of a VEGFA enhancer polymorphism selectively binding CHOP/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone

Ahluwalia, Tarunveer Singh, Troelsen, Jesper Thorvald, Balslev-Harder, Marie, Bork-Jensen, Jette, Thuesen, Betina Heinsbæk, Cerqueira, Charlotte, Linneberg, Allan, Grarup, Niels, Pedersen, Oluf, Hanse

Journal:

Journal of Medical Genetics

Year:

2017

Language:

english

File:

PDF, 1.44 MB

english, 2017

44

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream ofCDKN2AandCDKN2B

M. L. Hribal, I. Presta, T. Procopio, M. A. Marini, A. Stančáková, J. Kuusisto, F. Andreozzi, A. Hammarstedt, P.-A. Jansson, N. Grarup, T. Hansen, M. Walker, N. Stefan, A. Fritsche, H. U. Häring, O. P

Journal:

Year:

2011

Language:

english

File:

PDF, 166 KB

english, 2011

45

Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1

S. S. Torekov, L. Ma, N. Grarup, B. Hartmann, I. A. Hainerová, U. Kielgast, H. Kissow, M. Rosenkilde, GIANT Consortium, J. Lebl, D. R. Witte, T. Jørgensen, A. Sandbaek, T. Lauritzen, O. D. Madsen, J.

Journal:

Year:

2011

Language:

english

File:

PDF, 243 KB

english, 2011

46

Ritonavir-boosted darunavir combined with raltegravir or tenofovir–emtricitabine in antiretroviral-naive adults infected with HIV-1: 96 week results from the NEAT001/ANRS143 randomised non-inferiority trial

Raffi, François, Babiker, Abdel G, Richert, Laura, Molina, Jean-Michel, George, Elizabeth C, Antinori, Andrea, Arribas, Jose R, Grarup, Jesper, Hudson, Fleur, Schwimmer, Christine, Saillard, Juliette,

Journal:

Year:

2014

Language:

english

File:

PDF, 395 KB

english, 2014

47

No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels

Scott, R. A., Chu, A. Y., Grarup, N., Manning, A. K., Hivert, M.-F., Shungin, D., Tonjes, A., Yesupriya, A., Barnes, D., Bouatia-Naji, N., Glazer, N. L., Jackson, A. U., Kutalik, Z., Lagou, V., Marek,

Journal:

Year:

2012

Language:

english

File:

PDF, 147 KB

english, 2012

48

Passive Smoking Is Associated with Poor Asthma Control during Pregnancy: A Prospective Study of 500 Pregnancies

Grarup, Pernille A., Janner, Julie H., Ulrik, Charlotte Suppli, Kostikas, Konstantinos

Journal:

Year:

2014

Language:

english

File:

PDF, 174 KB

english, 2014

49

Screening of 31 genes involved in monogenic forms of obesity in 23 Pakistani probands with early-onset childhood obesity: a case report

Niazi, Robina Khan, Gjesing, Anette Prior, Hollensted, Mette, Have, Christian Theil, Borisevich, Dmitrii, Grarup, Niels, Pedersen, Oluf, Ullah, Asmat, Shahid, Gulbin, Shafqat, Ifrah, Gul, Asma, Hansen

Journal:

BMC Medical Genetics

Year:

2019

Language:

english

File:

PDF, 780 KB

english, 2019

50

Genetic Determinants of Electrocardiographic P-wave Duration and Relation to Atrial Fibrillation

Weng, Lu-Chen, Hall, Amelia Weber, Choi, Seung Hoan, Jurgens, Sean J., Haessler, Jeffrey, Bihlmeyer, Nathan A., Grarup, Niels, Lin, Honghuang, Teumer, Alexander, Li-Gao, Ruifang, Yao, Jie, Guo, Xiuqin

Journal:

Circulation: Genomic and Precision Medicine

Year:

2020

File:

PDF, 500 KB

2020

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